HUMAN PANTOTHENIC ACID DEFICIENCY PRODUCED BY OMEGA-METHYL PANTOTHENIC ACID *

Pantothenic acid deficiency induced in human subjects.

Bean and Hodges (1) gave a preliminary report of four young men in whom clinical disorders and metabolic faults were induced by a "diet" devoid of pantothenic acid, with omega-methylpantothenic acid, a vitamin antagonist (Figure 1). It is proposed here to describe details of the experiments, results, and some interpretations. The background for using molecular antagonists (2, 3) in human nutrit...

The modification of choline deficiency by simultaneous pantothenic acid deficiency.

It was found recently (1) that feeding a cholesterol-rich diet to pantothenic acid-deficient rats did not result in the fatty livers and high levels of cholesterol in liver and serum seen in comparable animals maintained on a normal diet. Decrease in food intake appeared not to account for this phenomenon, since the food intake of the deficient group on a body weight basis was higher than that ...

Cholesterol metabolism in pantothenic acid deficiency.

Pantothenic acid synthesis by smooth Brucella abortus.

The relationship between formation of exogenous alanine and the establishment of nonsmooth variants in originally smooth cultures of Brucella abortus strains has been clearly demonstrated (Goodlow et al., 1950). Furthermore, the addition of D-alanine to smooth cultures in synthetic medium (Gerhardt and Wilson, 1948) results in earlier establishment of nonsmooth cells (Goodlow et al., 1951). Sub...

Microbic Decomposition of Pantothenic Acid.